From targeted therapies in HER2-mutant lung cancer to the latest Alzheimer’s data with Kisunla, this month’s breakthroughs could reshape patient care. We unpack 10 high-impact studies and trials, including new insights on ILD–cancer links, the HOPE trial in late-window stroke thrombolysis, phenotype-specific benefits of CPAP, and kidney-protective strategies in diabetic CKD. Designed for clinicians, this deep dive blends the latest evidence with real-world clinical implications.