Mornings with Megan

10: Why Your Gut Went Rogue in Perimenopause (Part 1)


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If you suddenly developed bloating, food sensitivities, or digestive issues in your 40s that you never had before - you're not imagining it. Your gut microbiome is actually changing because of your hormones.

In this episode, I break down the perimenopause-gut connection that nobody's talking about:

  • How estrogen and progesterone manage your gut (and what happens when they drop)
  • The estrobolome: bacteria that metabolize and recycle estrogen
  • Why gut and vaginal microbiomes are connected (the gut-vagina axis)
  • The real reason UTIs, yeast infections, and BV became more common
  • How gut health affects hot flashes, mood, sleep, and insulin resistance
  • Why over-sanitizing is destroying your protective bacteria
  • The critical connection between oral health and gut health in perimenopause

This is Part 1 of our gut health series. Next week we dive into the practical protocol - what to eat, fermented foods, the 40 plant foods framework, probiotics, and my exact antibiotic protocol.

Your gut isn't broken. Your perimenopause isn't in your head. Understanding what's happening is the first step.


Time Stamps

00:00 Understanding Gut Health and Its Importance03:21 The Impact of Hormones on Gut Microbiome06:10 The Connection Between Gut and Vaginal Health09:29 Maintaining a Healthy Microbiome10:54 Oral Health's Role in Gut Health13:19 Practical Steps for Gut Health During Perimenopause


🧬 Ready to stop guessing?

I help women interpret their labs so they can make nutrition decisions based on data, not diet trends.

šŸ‘‰ Book your personalized Lab Review here

šŸŽ FREE RESOURCE: Download the free Perimenopause Decoder . It helps you understand what's happening during perimenopause so you can make decisions from a place of clarity, not chaos.


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You're not crazy. You're not broken. You're not alone. And you absolutely deserve to feel like yourself again.


Full Episode Show Notes


#Perimenopause #GutHealth #Microbiome #WomensHealth #Hormones #Nutrition #MorningsWithMegan #PerimenopauseMatrix

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Mornings with MeganBy Megan Pfiffner