Opioid overdoses are killing about 50,000 Americans a year, more than car accidents and guns. Marketplace's documentary podcast, The Uncertain Hour, is digging into drug epidemics in its latest season: why people buy and sell drugs, how law enforcement tries to stop them and how an epidemic eventually ends. Reporter and producer Caitlin Esch spoke with Kai and Molly about going back to Wise County, Virginia, a sort of ground zero of the current opioid epidemic, and about how the stories told by some of her sources speak to wider issues in the crisis. Just a note: there is one swear word in this episode, around 8 minutes in.You can subscribe to The Uncertain Hour here, and don't forget you can watch this and other episodes of Make Me Smart on our YouTube channel.Today's show is sponsored by Panopto, Wasabi Hot Cloud Storage, Alliance for Lifetime Income  and Mailchimp