Hour 2 centers on a deep comparison between the crack epidemic and the ongoing opioid crisis. Sherwin examines the socioeconomic impacts of both and questions why the differences are often ignored. He briefly pivots to a protest incident where a white woman attempted to use a tragedy to promote an anti-marijuana petition. Later, Sherwin discusses overlooked dangers harming Black communities—such as house fires—and questions why these issues don’t spark the same level of protest. Callers join the discussion, debating drug use and addiction, prompting Sherwin to push back against what he sees as the glorification of heroin. A PSA highlighting the severity of the opioid crisis plays before Sherwin wraps the hour by openly debating whether to continue the show.