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#130 Organ transplantation part 1: Neuroinfectious complications
There is no question that organ transplantation has saved thousands of lives in recent years from fatal conditions. And over time, we've become more and more successful at maintaining the integrity of the graft and increasing longevity of organ transplant recipients. Despite these advances in transplant medicine, it is not an entirely risk-free process. In part 1 of this 2-part series of the BrainWaves podcast, Jim Siegler speaks with Dr. Linda Zhou about the neuroinfectious complications that threaten these patients.
Produced by James E. Siegler and Linda Zhou. Music by Jason Shaw, Josh Woodward, and Lee Rosevere. Sound effects by Mike Koenig and Daniel Simion. BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision making. Be sure to follow us on Twitter @brainwavesaudio for the latest updates to the podcast.
REFERENCES
- Pruitt AA. Central Nervous System Infections Complicating Immunosuppression and Transplantation. Continuum (Minneap Minn). 2018;24:1370-1396.
- Dhar R. Neurologic complications of transplantation. Handbook of clinical neurology. 2017;141:545-572.
- Salovin A, Glanzman J, Roslin K, Armangue T, Lynch DR and Panzer JA. Anti-NMDA receptor encephalitis and nonencephalitic HSV-1 infection. Neurol Neuroimmunol Neuroinflamm. 2018;5:e458.
- Srinivasan A, Burton EC, Kuehnert MJ, Rupprecht C, Sutker WL, Ksiazek TG, Paddock CD, Guarner J, Shieh WJ, Goldsmith C, Hanlon CA, Zoretic J, Fischbach B, Niezgoda M, El-Feky WH, Orciari L, Sanchez EQ, Likos A, Klintmalm GB, Cardo D, LeDuc J, Chamberland ME, Jernigan DB, Zaki SR and Rabies in Transplant Recipients Investigation T. Transmission of rabies virus from an organ donor to four transplant recipients. The New England journal of medicine. 2005;352:1103-11.
- Vora NM, Basavaraju SV, Feldman KA, Paddock CD, Orciari L, Gitterman S, Griese S, Wallace RM, Said M, Blau DM, Selvaggi G, Velasco-Villa A, Ritter J, Yager P, Kresch A, Niezgoda M, Blanton J, Stosor V, Falta EM, Lyon GM, 3rd, Zembower T, Kuzmina N, Rohatgi PK, Recuenco S, Zaki S, Damon I, Franka R, Kuehnert MJ and Transplant-Associated Rabies Virus Transmission Investigation T. Raccoon rabies virus variant transmission through solid organ transplantation. JAMA : the journal of the American Medical Association. 2013;310:398-407.
- Fischer SA, Lu K and Practice ASTIDCo. Screening of donor and recipient in solid organ transplantation. Am J Transplant. 2013;13 Suppl 4:9-21.
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By Jim Siegler, MD | Neurologist | Father | Friend of dogsThere is no question that organ transplantation has saved thousands of lives in recent years from fatal conditions. And over time, we've become more and more successful at maintaining the integrity of the graft and increasing longevity of organ transplant recipients. Despite these advances in transplant medicine, it is not an entirely risk-free process. In part 1 of this 2-part series of the BrainWaves podcast, Jim Siegler speaks with Dr. Linda Zhou about the neuroinfectious complications that threaten these patients.
Produced by James E. Siegler and Linda Zhou. Music by Jason Shaw, Josh Woodward, and Lee Rosevere. Sound effects by Mike Koenig and Daniel Simion. BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision making. Be sure to follow us on Twitter @brainwavesaudio for the latest updates to the podcast.
REFERENCES
- Pruitt AA. Central Nervous System Infections Complicating Immunosuppression and Transplantation. Continuum (Minneap Minn). 2018;24:1370-1396.
- Dhar R. Neurologic complications of transplantation. Handbook of clinical neurology. 2017;141:545-572.
- Salovin A, Glanzman J, Roslin K, Armangue T, Lynch DR and Panzer JA. Anti-NMDA receptor encephalitis and nonencephalitic HSV-1 infection. Neurol Neuroimmunol Neuroinflamm. 2018;5:e458.
- Srinivasan A, Burton EC, Kuehnert MJ, Rupprecht C, Sutker WL, Ksiazek TG, Paddock CD, Guarner J, Shieh WJ, Goldsmith C, Hanlon CA, Zoretic J, Fischbach B, Niezgoda M, El-Feky WH, Orciari L, Sanchez EQ, Likos A, Klintmalm GB, Cardo D, LeDuc J, Chamberland ME, Jernigan DB, Zaki SR and Rabies in Transplant Recipients Investigation T. Transmission of rabies virus from an organ donor to four transplant recipients. The New England journal of medicine. 2005;352:1103-11.
- Vora NM, Basavaraju SV, Feldman KA, Paddock CD, Orciari L, Gitterman S, Griese S, Wallace RM, Said M, Blau DM, Selvaggi G, Velasco-Villa A, Ritter J, Yager P, Kresch A, Niezgoda M, Blanton J, Stosor V, Falta EM, Lyon GM, 3rd, Zembower T, Kuzmina N, Rohatgi PK, Recuenco S, Zaki S, Damon I, Franka R, Kuehnert MJ and Transplant-Associated Rabies Virus Transmission Investigation T. Raccoon rabies virus variant transmission through solid organ transplantation. JAMA : the journal of the American Medical Association. 2013;310:398-407.
- Fischer SA, Lu K and Practice ASTIDCo. Screening of donor and recipient in solid organ transplantation. Am J Transplant. 2013;13 Suppl 4:9-21.