Do you brush and floss every day yet still struggle with bad breath that just won’t go away?

In this revealing episode of Dental Formulator’s Playbook, Dr. Robert L. Karlinsey and co-host Tami explore the underexamined science of halitosis — debunking myths, exposing the biochemical causes of bad breath, and dissecting why certain mouthwashes work while others fall short.

From volatile sulfur compounds (VSCs) to regulatory blind spots, they explain why halitosis persists, which ingredients actually make a difference, and how sodium chlorite performs (or fails) depending on activation conditions and formulation design.

This episode is a must-listen for formulators, clinicians, and anyone seeking long-lasting fresh breath backed by real research—not just clever marketing.

🔥 Highlights ↠

• Volatile Truths: Dr. Rob identifies the real culprits behind halitosis — hydrogen sulfide, methyl mercaptan, and dimethyl sulfide — explaining how these “stinky” sulfur gases arise from the tongue and throat, even in people with excellent oral hygiene.
• Cosmetic or Clinical?: The FDA classifies bad breath as a cosmetic condition, not a disease. That means no official monograph, no approved actives, and plenty of gray area for marketing claims — and consumer confusion.
• Sniff Tests & Science: Learn how researchers measure odor scientifically, from human sniff panels to gas chromatography, and why both approaches are essential to proving product efficacy.
• Sodium Chlorite vs. Zinc Salts: A 2014 South Korean study found that 0.16% sodium chlorite outperformed zinc chloride and chlorhexidine, reducing VSCs almost instantly and maintaining effects for up to 60 minutes.
• Activation Matters: Whether dual-chamber mouthwashes like SmartMouth or single-bottle formulas like TheraBreath, Dr. Rob explains how acidic environments and pH activation determine ingredient effectiveness.
• Formula Forensics Preview: Discover why some impressive-sounding ingredients fail in real-world tests — and why combining sodium chlorite with CPC might be promising (though scientifically tricky).
• Chicken Carcasses & the FDA?! You read that right. Sodium chlorite is technically regulated for poultry processing but not for oral care. The lack of FDA guidance leaves formulators connecting dots across industries to ensure compliance and safety.
• Marketing vs. Science: Dr. Rob and Tami discuss why ADA Seals still matter (kind of), how legacy brands leverage language to imply claims, and how to look past buzzwords when choosing an oral care product.

Key Takeaways

• Bad breath isn’t just a hygiene issue — it’s biochemical.
• Sodium chlorite outperforms zinc chloride and chlorhexidine for VSC elimination.
• Mouthwash efficacy depends on smart formulation, proper pH, and validated testing.

📲 Connect with Dr. Rob (Robert L. Karlinsey, PhD)

🌐 Website: customdentalformulations.com

📄 Research Profile: Robert Karlinsey on ResearchGate