Holobiont

#15 Atypical T cell responses: HLA-E Immunology

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Sir Andrew McMichael is a Professor of Immunology at the University of Oxford and previously Director of the Weatherall Institute of Molecular Medicine. He is a fellow of the Royal Society and Academy of Medical Sciences and has been a leader in human immunology for decades, notably  focusing on responses to viral infections including influenza and HIV.

We discuss:

  • Prof McMichael's career in immunology spanning from his work in the 1980s on HLA restriction and recognition of viral peptides to the study of a HLA-E, an atypical MHC-Ib molecule that is involved in immunosurveillance 
  • How HLA-E is involved in detection of the "missing self" by Natural Killer (NK) cells 
  • The discovery of a class of CD8+ T cells recognising HLA-E complexes and their role in protection against SIV infection 
  • The opportunities and unanswered questions in  HLA-E immunobiology
  • Advice to scientists 




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    HolobiontBy Ursule Demael