This podcast explores the intersection of ontologies, Large Language Models (LLMs), and Vertical AI Agents. Ontologies, as formal knowledge representations, enhance LLMs' ability to construct and enrich knowledge frameworks, leading to improved reasoning and decision-making in AI systems. LLMs automate ontology construction and matching, streamlining development. Vertical AI agents, specializing in niche applications, leverage ontologies for tailored solutions. While promising, scalability, complexity, and maintenance pose challenges. Future directions involve standardizing frameworks and integrating ontologies deeper into AI to enhance reasoning and accuracy, with applications across healthcare, finance, and supply chain management.