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March 06, 2019

2. An emerging technology is always not perfect

54 minutes

CRISPR-Cas9使ったゲノム編集の歴史、Off-target問題、1塩基ゲノム編集、バクテリアへのデータ保存、Anti-CRISPRタンパクなどについて話しました。Show notes

Multiplex Genome Engineering Using CRISPR/Cas Systems. Cong et al., Science 2012

RNA-Guided Human Genome Engineering via Cas9. Mali et al., Science 2012

Rationally engineered Cas9 nucleases with improved specificity. Slaymaker et al., Science 2016

High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects. Kleinstiver et al., 2016 Nature

Ethics aside, does the CRISPR baby experiment make scientific sense?

声明：ゲノム編集を実施したヒト受精卵から女児を誕生させたとの発表に対する懸念, 日本ゲノム編集学会

Guidelines for base editing in mammalian cells

CRISPR-Cas encoding of a digital movie into the genomes of a population of living bacteria. Shipman et al., 2017 Nature

ウェットなデータストレージメディアとしてのDNA. 実験医学2019年1月号

Naturally Occurring Off-Switches for CRISPR-Cas9. Pawluk et al., Cell 2016

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