This lecture summarizes various multi-modalanalgesic options to optimize pain management post-cesarean delivery. The role of neuraxialopioids, non-steroidal anti-inflammatories, acetaminophen, gabapentin, wound infiltration, transversus abdominis plane block, and future analgesic options will be reviewed. Analgesic drug exposure in breastfeeding neonates, and techniques to minimize the transfer of analgesics into breast milk will also be discussed.