F* It!

209 - GLP-1s: 7 Things You Need to Know Before You Jump On

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GLP-1 medications like Ozempic, Wegovy, and Mounjaro are everywhere — and the research backs them up. But there’s a conversation almost nobody is having: what happens after? In this episode, Amy breaks down what these drugs actually do, what they don’t do, and what has to be built alongside them if you want results that last. This is not an argument against GLP-1s. It’s an argument against using them as a standalone solution.

 

In This Episode

  • What GLP-1 drugs are and how they work (the actual mechanism)
  • The BMJ review and what the data says about weight regain after stopping
  • Why appetite suppression ≠ behaviour change (and Amy’s Fen-Phen story)
  • The muscle loss problem — and why it matters more than most people realise
  • “No man’s land” — why women who’ve been on GLP-1s for years still aren’t losing
  • What you actually have to build nutritionally while on the drug
  • Long-term use — and why habits are non-negotiable either way
  • Why the drug is a tool, not the strategy — and what the strategy actually looks like

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    Research Referenced

    • The BMJ — large review of weight-loss medication outcomes in 9,000+ participants
    • Semaglutide clinical trial data (STEP trials) — avg ~15% body weight loss
    • Tirzepatide trial data (SURMOUNT trials) — avg ~20-22% body weight loss
    • Lean mass loss studies during GLP-1 use

      • Thank you for being here — whether this is your first episode or you’ve been with me since Episode 1.

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      F* It!By Amy Ledin
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