Orders of Magnitude

21. A story of science's self-correction


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In today's episode, Philippe tells us about how scientists studying a cell-stress management protein got into a lengthy argument over mistakes found in their published work. This is a great example of how science has the ability to correct its own mistakes over time.

References:

Yang, Peiguo, et al. "G3BP1 is a tunable switch that triggers phase separation to assemble stress granules." Cell 181.2 (2020): 325-345.


Panas, Marc D et al. “Phosphorylation of G3BP1-S149 does not influence stress granule assembly.” The Journal of cell biology vol. 218,7 (2019): 2425-2432. doi:10.1083/jcb.201801214


Tourrière, Hélène, and Jamal Tazi. “Reply to "Phosphorylation of G3BP1-S149 does not influence stress granule assembly".” The Journal of cell biology vol. 218,7 (2019): 2433-2434. doi:10.1083/jcb.201905105


Kedersha, Nancy, et al. "Correction: G3BP–Caprin1–USP10 complexes mediate stress granule condensation and associate with 40S subunits." Journal of Cell Biology 219.1 (2020).


Tourrière, Hélène, et al. "The RasGAP-associated endoribonuclease G3BP assembles stress granules." The Journal of cell biology 160.6 (2003): 823-831.

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Orders of MagnitudeBy Science Communication Orders of Magnitude