the bioinformatics chat

#21 Linear mixed models, GWAS, and lme4qtl with Andrey Ziyatdinov

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Linear mixed models are used to analyze GWAS data and detect QTLs.

Andrey Ziyatdinov recently released an R package, lme4qtl, that can be used to
formulate and fit these models.
In this episode, Andrey and I discuss linear mixed models, genome-wide association studies, and strengths and weaknesses of lme4qtl.

Links:

  • Paper: lme4qtl: linear mixed models with flexible covariance structure for genetic studies of related individuals
  • lme4qtl on GitHub

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