Hurler syndrome, also known as mucopolysaccharidosis Type IH (MPS-IH),  Hurler's disease, and formerly gargoylism, is a genetic disorder that  results in the buildup of large sugar molecules called  glycosaminoglycans (GAGs) in lysosomes. The inability to break down  these molecules results in a wide variety of symptoms caused by damage  to several different organ systems, including but not limited to the  nervous system, skeletal system, eyes, and heart. Allogeneic  hematopoietic stem-cell transplantation is the standard of care for  Hurler syndrome (mucopolysaccharidosis type I, Hurler variant [MPSIH]).  However, this treatment is only partially curative and is associated  with complications.