Dive deep into the fascinating world of cannabinoid science as we explore how the brain adapts to long-term cannabis use. This episode unravels the complex dance between cannabinoids and our neural pathways, explaining how tolerance develops through receptor down-regulation and altered brain chemistry.

From the intricate workings of CB1 and CB2 receptors to the molecular relay race of G-protein signaling, we break down the science into digestible concepts while exploring cutting-edge research in functional selectivity and potential therapeutic applications. Whether you're interested in neuroscience, medicine, or simply curious about how cannabis affects the brain, this episode offers valuable insights into the delicate balance between beneficial use and dependence.