This podcast episode explores future developments and ongoing debates in psychedelic medicine, covering key topics like personalized medicine approaches, whole plant reconstruction versus isolated compounds, and polypharmacy in psychedelic therapy. The discussion delves into emerging areas like non-psychotropic psychedelics, the role of the gut microbiome in psychedelic responses, and the development of designer psychedelics. The hosts examine both the promising potential and important challenges facing the field, emphasizing the need for careful research, ethical considerations, and responsible development of these therapies.