This podcast episode explores the complex challenges of blinding in psychedelic research studies. The discussion delves into why traditional blinding methods often fall short when studying substances like MDMA, LSD, and DMT. Key topics include:

- The role of physical indicators like body temperature changes in MDMA studies

- How different psychedelics interact with 5HT2A receptors through "functional selectivity"

- The influence of set, setting, and participant expectations on study outcomes

- The use of active placebos and innovative research methodologies to address blinding challenges