This podcast episode explores the controversies and challenges in psychedelic science, covering key topics including:

- MDMA-assisted therapy's potential for PTSD treatment and psilocybin's promise for treatment-resistant depression

- The importance of set, setting, and positive intentions in psychedelic experiences

- The role of 5-HT2A and NMDA receptors in psychedelic effects, including potential risks like HPPD and neurotoxicity

- Legal and cultural considerations, including the evolving regulatory landscape and cultural significance of psychedelics

- Ethical frameworks for research and therapy, emphasizing the need for careful screening, controlled doses, and supportive settings