This podcast episode explores the safety and toxicology of psychedelic substances, with a particular focus on MDMA and LSD. The discussion covers key mechanisms of action through the 5HT2A receptor, potential risks like neurotoxicity and serotonin syndrome, and the importance of careful monitoring in clinical settings. The episode delves into how different psychedelics interact with the brain, including their effects on the default mode network and neuroplasticity. Special attention is given to the role of set and setting in psychedelic therapy and the significance of personalized approaches to treatment.