This podcast episode explores the long-term effects of psychedelics on the brain, discussing key concepts like receptor-mediated neuroplasticity and the importance of set and setting. The conversation covers various substances including MDMA, LSD, and ayahuasca, examining both their therapeutic potential and possible risks. Important topics include:

- The role of BDNF in brain plasticity and neural connections

- Potential risks like heart valve issues (valvulopathies) with MDMA

- The impact on the default mode network and consciousness

- The importance of responsible use and proper integration of psychedelic experiences