This podcast episode explores how animal studies help us understand psychedelic effects in humans, with a particular focus on receptor homology and the "lock and key" system of 5HT2A receptors. The discussion covers key research findings about MDMA, including temperature sensitivity and multiple receptor interactions, as well as LSD's effects on brain activity and consciousness. The episode also delves into therapeutic applications, examining how findings from animal studies translate to human treatments for conditions like PTSD, depression, and anxiety.