This podcast episode provides an in-depth exploration of DMT's pharmacology, focusing on its unique interactions with brain receptors. The discussion covers DMT's remarkably fast action through the 5-HT2A receptorand its interaction with the Sigma-1 receptor, which may play a role in neuroprotection. The hosts explore how DMT's rapid metabolism by MAO enzymes contributes to its short durationand discuss potential therapeutic applications, including research on depression, anxiety, and addiction. The episode also delves into the importance of set and setting, brain imaging studies showing DMT's effects on neural connectivity, and the development of DMT analogs for research purposes.