This podcast episode provides an in-depth exploration of 5-MeO-DMT, discussing its pharmacological mechanisms and therapeutic potential. The conversation covers how the substance interacts with serotonin receptors (5HT2A and 5HT1A), its effects on synaptic plasticity, and its uniquely rapid metabolism through MAO enzymes. The hosts examine the importance of set and setting in psychedelic experiences, citing the Borkel study from 2024 which found that natural settings and presence of loved ones led to better outcomes. The discussion also touches on safety considerations, potential risks, and the future of personalized psychedelic therapy, including possible applications of VR in therapeutic settings.