While tracking the progression of mass insanity across the galaxy, the Enterprise arrives at the planet Deneva, where the inhabitants have been infected by invading parasites that control their human hosts with immense pain. If Captain Kirk cannot destroy the parasites and cure the more than one million colonists, he will be forced to make the most difficult command decision of his life in an effort to stop the madness from progressing any further. The landmark first season of "Star Trek" came to a close with "Operation -- Annihilate!", a flawed episode that hardly represents the best of the series, though its depiction of agony certainly one of the most disturbing to endure. But it still has many merits, the biggest of which are the top-notch performances from William Shatner, Leonard Nimoy and DeForest Kelley, who continued to strengthen the incredible dynamic between Kirk, Spock and McCoy.

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