the bioinformatics chat

#35 The role of the DNA shape in transcription factor binding with Hassan Samee

Listen Later

Even though the double-stranded DNA has the famous regular helical shape,

there are small variations in the geometry of the helix depending on what
exact nucleotides its made of at that position.

In this episode of the bioinformatics chat, Hassan Samee talks about the

role the DNA shape plays in recognition of the DNA by DNA-binding proteins,
such as transcription factors. Hassan also explains how his algorithm, ShapeMF,
can deduce the DNA shape motifs from the ChIP-seq data.

Links:

  • A De Novo Shape Motif Discovery Algorithm Reveals Preferences of Transcription Factors for DNA Shape Beyond Sequence Motifs (Md. Abul Hassan Samee, Benoit G. Bruneau, Katherine Pollard)
  • ShapeMF on GitHub
  • A picture explaining some of the DNA shape features

    • If you enjoyed this episode, please consider supporting the podcast on Patreon.

    ...more
    View all episodesView all episodes
    Download on the App Store
    the bioinformatics chatBy Roman Cheplyaka
    • 4.7
    • 4.7
    • 4.7
    • 4.7
    • 4.7

    4.7

    35 ratings