Spondylolisthesis Treatment *Medications. Pain medications, such as acetaminophen, and/or NSAID's (e.g. ibuprofen, COX-2 inhibitors) or oral steroids to reduce inflammation in the area. *Heat and/or ice application. *Physical Therapy. *Manual manipulation. *Epidural steroid Injections. *Spondylolisthesis Surgery.

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