Especial Guest: Dr. Stephaun Wallace, PhD  Director of External Relations, HIV Vaccine Trials Network and COVID-19 Prevention Network. June 2021 marks the 40th anniversary of the first description of AIDS. We present our personal reflections on scientific and global health evolution over the fourth decade of AIDS in a world that has recently suffered other major epidemics. We focus on biomedical advances because these have had the greatest effect on HIV transmission and disease