In this episode, we present a curated countdown of the ten most influential research papers published in 2025 regarding AI-driven drug discovery and computational biology. The collection highlights a significant transition from human-led laboratory tasks to autonomous AI scientists and multi-agent orchestration, in which intelligent systems independently manage complex research cycles. Key technological themes include the creation of "virtual cell" foundation models trained on massive single-cell datasets, the use of generative protein design to surpass natural evolution, and the application of chemical language models for molecular synthesis. Ultimately, the source serves as a strategic roadmap, illustrating how the convergence of large-scale multimodal data and agentic reasoning is fundamentally accelerating the timeline and efficiency of modern pharmaceutical development. Produced by Dr. Jake Chen.