The 65th meeting ever between Arizona and San Francisco as Kyler Murray and the Cardinals are coming off a bye week in week XIV, while Brock Purdy and the 49ers are coming a divisional win. Arizona won on the road in week XIII before their BYE so the question is can they continue winning?

49ers @ Cardinals XV

During the NFL season and postseason here at The Prophet’s Picks, I will predict which NFL team will win before the games are played! Since 1995 I’ve done this successfully. During the off-season, I will keep you up to date with what’s going on with your favorite NFL team. Only the truth will be unleashed. No holds barred, no filter, no hogwash here on The Prophet’s Picks.

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49ers @ Cardinals XV

49ers @ Cardinals XV