Jimmy Garappolo is back in the driver's seat coming off a M.N.F. win to end week IV. Carolina is coming off a bad home performance, more so for Baker Mayfield than for the Panthers sneaky good defense. This is meeting number 23 between these former NFC West rivals and S.F. doesn't lead but won that 2014 postseason game.

49ers @ Panthers week V

During the NFL season and postseason here at The Prophet’s Picks, I will predict which NFL team will win before the games are played! Since 1995 I’ve done this successfully. During the off-season, I will keep you up to date with what’s going on with your favorite NFL team. Only the truth will be unleashed. No holds barred, no filter, no hogwash here on The Prophet’s Picks.

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49ers @ Panthers week V

49ers @ Panthers week V