The 49ers and Rams have played each other 148 times since 1950. This is meeting number 149 and Matthew Stafford's Rams looked good on the road in the division in Seattle week one winning almost effortlessly. So did the 49ers, Brock Purdy's pretty play is back with a vengeance it seems and the Rams haven't defeated the 49ers in the regular season since 12-2018. 8 game regular season losing streak to an NFC West, familiar opponent.