49ers vs Rams Week 5, 2025: Thursday Night Football Prediction49ers vs Rams is the Week 4 Thursday Night Football match-up! Can Matthew Stafford & Puka Nacua continue their dominance for the Rams? Or will Brock Purdy & Christian McCaffrey get the 49ers back on track? Here is my prediction for 49ers vs Rams on Thursday Night Football!0:00 Intro1:14 49ers vs Rams Preview9:30 Winner10:56 Outro#LosAngelesRams #SanFrancisco49ers #TNF #ThursdayNightFootball #49ers #LARams #NFLPredictions