Nannie Doss, mainly known as the Giggling Granny, was a serial killer from the 1920s to the 1950s. Killing nothing but family members, this ruthless serial killer made it decades before anyone caught on to her games. 

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Resources:

https://allthatsinteresting.com/nannie-doss-giggling-granny

https://murderpedia.org/female.D/d/doss-nannie.htm

Scribd: The Giggling Granny: Serial Killer Nannie Doss