First we had alpha, beta, and delta, and now we have hundreds of sublineages just from omicron alone. Virologist Dr. Andy Pekosz returns to the podcast to talk with Dr. Josh Sharfstein about how experts are keeping track of so many variations of SARS-CoV-2, which advantageous mutations most lineages are picking up to help them spread, the clinical impacts on treatments and vaccines, and why COVID-19 is not yet seasonal.