the bioinformatics chat

#6 Allele-specific expression

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I talk about allele-specific expression: why it arises and how it can be

reliably detected.

Sections:

  • The biology of allele-specific expression (2:17)
  • Detecting allele-specific expression with RNA-seq (7:46)
  • Mapping and sequencing biases (16:39)
  • The experiment in yeast (19:47)
  • Statistical models (21:44)

    • Links:

    • A powerful and flexible statistical framework for testing hypotheses of
      • allele-specific gene expression from RNA-seq data
      • Supplemenal information
      • Effect of read-mapping biases on detecting allele-specific expression from RNA-sequencing data
      • The talk by John Marioni
      • The blog post explaining the RSEM model

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        the bioinformatics chatBy Roman Cheplyaka
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