In the frenzy of research for COVID-19 prevention and treatment, there were many disagreements about what really did—or didn't—work. The nature of the debates reveals a broader problem in how data are interpreted in medicine. Dr. Arturo Casadevall and Dr. Josh Sharfstein discuss the nature of evidence and Dr. Casadevall's new paper, Misinterpretation of Clinical Research Findings and COVID-19 Mortality. You can read the paper here: https://www.acpjournals.org/doi/full/10.7326/M23-0737?af=R