PEPFAR, or the President's Emergency Plan for AIDS Relief, was initiated by President Bush in 2003 is credited with saving 25 million lives over the past 20 years and remains the largest commitment to a single disease in history. But the global bipartisan program is now at the mercy of American politics. Dr. Chris Beyrer, director of the Duke Global Health Institute and a member of the scientific advisory board for PEPFAR, returns to the podcast to talk with Stephanie Desmon about why PEPFAR's reauthorization is in jeopardy and what the failure of reauthorization could mean for global health.