In this BrainWaves brief, we review the major infections of the spinal cord with anatomic localization of disease and clinical management. BrainWaves podcasts and online content are intended for medical education only and should not be used to guide medical decision making in routine clinical practice. Any cases discussed in this episode are fictional and do not contain any patient health identifying information. This episode was vetted and approved by Colin Quinn. REFERENCES 1. Cho TA, Vaitkevicius H. Infectious myelopathies. Continuum (Minneap Minn). 2012;18(6):1351-1373.