This episode of The Addiction Files breaks down kratom’s pharmacology with a focus on 7-hydroxymitragynine (7-OH), a potent opioid-active compound driving many of its effects. It highlights the growing risks of high-potency products, including dependence and toxicity. A concise, clinically relevant overview for recognizing and managing kratom-related presentations. Hosted by Darlene Petersen, MD FAAFP and Paula Donnelly Cook, MD FASAM.

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