In 2012, comedian Tig Notaro’s stand-up set, in which she boldly began with the line “Hello. Good evening. I have Cancer,” catapulted her into the national spotlight and led to numerous late show appearances, book and film deals. In this hilarious and candid interview, she explains why her belief in her own voice has never wavered, her unusual family, and how she tackled tough subjects such as sexual assault, loss, and love on her semi-autobiographical television show *One Mississippi. *