Oncogenic alterations underlying B-cell acute lymphoblastic leukemia  (B-ALL) in adults remain incompletely elucidated. To uncover novel  oncogenic drivers, Marie and her team performed RNA-seq and whole-genome  analyses in a large cohort of unresolved B-ALL. Marie and colleagues  identified a novel subtype characterized by a distinct gene expression  signature and the unique association of two genomic microdeletions.   Article link: https://ashpublications.org/blood/article/doi/10.1182/blood.2021014723/484449/Concurrent-CDX2-cis-deregulation-and-UBTF-ATXN7L3