Ask Stago (english version)

#8 What are sensitivity and specificity performances of a diagnostic assay?

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Welcome to Ask Stago, the weekly podcast for Hemostasis laboratory professionals  

In today’s episode, with Lydie Nicoud, Director of Design and Biological Applications development, Cécile Hourquet and Audrey Carlo will try to better understand sensitivity and specificity of a diagnostic test, through some examples. 

Sources:  

  • CLSI, Quantitative D-dimer for the Exclusion of Venous Thromboembolic Disease, CLSI document H59-A, Wayne PA; Clinical Laboratory Standards Institute 2011 
  • Valentine Minet, Jean-Michel Dogné, and François Mullier, Functional Assays in the Diagnosis of Heparin-Induced Thrombocytopenia: A Review Molecules 22, no. 4 (April 11, 2017): 617, https://doi.org/10.3390/molecules22040617.
  •  Cuker A, Arepally GM, Chong BH, et al. American Society of Hematology 2018 guidelines for management of venous thromboembolism: heparin-induced thrombocytopenia. Blood Adv. 2018;2(22):3360-3392. doi:10.1182/bloodadvances.2018024489 
  •  Nagler M, Bachmann LM , ten Cate H, ten Cate-Hoek A, Diagnostic value of immunoassays for heparin-induced thrombocytopenia: a systematic review and meta-analysis. Blood 2016; 127 (5): 546–557. doi: https://doi.org/10.1182/blood-2015-07-661215

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    Content is scientific and technical in nature. It is intended as an educational tool for laboratory professionals and topics discussed are not intended as recommendations or as commentary on appropriate clinical practice.

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