In this week's episode we are joined by Isabelle Zane, a PhD student at the Wellcome Sanger Institute in Cambridge who is investigating the link between genetic mutations and protein function in the Lehner & Parts labs. We discuss a novel technology- deep mutational scanning- which is used to screen how single gene mutations influence the structure and/or function of proteins, thereby testing the relationship between genotype and phenotype. We also discuss methods used to study protein dynamics, including nuclear magnetic resonance (NMR) spectroscopy, X-ray crystallography, and more! Listen to find out more about the fascinating ways in which we can interrogate the relationship between DNA and the proteins they encode.

You can find Isabelle's cartoon creations about life and people in the lab on her twitter @isabellease

Today’s episode was made possible thanks to the support of the Biochemical Society public engagement fund. We would like to thank the Biochemical Society for the generous grant supporting Science Communication initiatives like these. ⁠⁠⁠⁠https://www.google.com/search?client=safari&rls=en&q=the+biochemical+society&ie=UTF-8&oe=UTF-8⁠⁠⁠

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