This podcast episode explores the fascinating world of cadherins and cell adhesion. The discussion breaks down how these essential proteins work as molecular "glue" to hold cells together, requiring calcium to function. The hosts explain different types of cadherins (E-cadherin for epithelial tissues, N-cadherin for neural tissues, and P-cadherin for placenta)and dive into how they form specialized adherens junctions. The conversation also covers how cadherins interact with the cytoskeleton, regulate contact inhibition, and help establish cell polarity.