This podcast episode provides a comprehensive exploration of olfactory receptors and how our sense of smell works. The discussion covers the molecular mechanisms of smell detection, from odor molecules binding to receptors through the complex signaling cascade involving G proteins and cAMP. The episode delves into specialized structures called glomeruli in the olfactory bulb that process smell signals, and examines how the brain interprets different scent combinations through combinatorial coding. The conversation also explores cutting-edge research on microdomains and their potential role in smell processing, while highlighting the fascinating connection between smell, memory, and emotions.