A Functional Approach with Dr. Jim Chialtas

Aging is often viewed as an inevitable, irreversible process—a fundamental rule of being human. But what if we are wrong? What if aging is not a destiny, but a condition to be treated, managed, and eventually overcome?

In this 189th episode, I sit down with James Strole, the Executive Director of the Coalition for Radical Life Extension and the visionary founder of RAADfest (The Revolution Against Aging and Death).

James has dedicated his career to the pursuit of "vibrant unlimited human lifespans," bridging the gap between cutting-edge scientific potential and the philosophical shifts required to embrace a new era of existence.

We move beyond the basic concept of "living a little longer" to dive into the philosophy of Radical Life Extension. From actionable, daily strategies regarding diet, exercise, and supplementation to profound questions about spirituality, the role of joy, and the impact of AI on our future purpose.  We also tackle the challenging ethical and societal questions, including how radical life extension might reshape our relationship with resources, the planet, and the very structure of our careers.

Whether you are looking for evidence-based practices to optimize your current healthspan or are curious about the futuristic technologies that could redefine mortality, this conversation challenges us to rethink everything we know about aging.

Connect with James Strole

• X: https://x.com/JamesRstrole
• LinkedIn: https://www.linkedin.com/in/jamesstrole/
• Facebook: https://www.facebook.com/james.strole.520
• IG: https://www.instagram.com/james.strole/
• Youtube: https://www.youtube.com/@PeopleUnlimitedInc

The Gospel of Longevity

• Learn more about James’ book and purchase a copy here:https://www.thegospeloflongevity.com
• Direct amazon link: https://www.amazon.com/Gospel-Longevity-James-R-Strole/dp/B0GWGP661R/ref=sr_1_1?crid=YRQ2CUSN56TZ&dib=eyJ2IjoiMSJ9.ffnyohKHIsVQac6eLWYIAGcDbmLGiLA5R3OBVB74Tz3GjHj071QN20LucGBJIEps.ZkK8gQ4hpcPUZUBHPoQEWzvctyjCn6IMEkeLl6eCt1o&dib_tag=se&keywords=the+gospel+of+longevity+by+james+strole&qid=1789512662&sprefix=the+gospel+of+lo%2Caps%2C224&sr=8-1

In this 188th episode, I sit with my good friend and colleague, Dr. Kit Yoon. We have a lovely conversation about all things midlife... Our "second Spring," so to speak.

This is a time of life when many people believe, or accept, that it is all downhill from here. But is it? Or perhaps this time of life is a time for us to look at those things which are most important. Perhaps it is a time to refine or redefine our life goals, relationships, or philosophies.

Come and sit with Dr. Kit and I as we speak openly with each other about our Second Spring... And quite possibly, yours as well. Our conversation flows between topics such as menopause, andropause (for men), Traditional Chinese Medicine, Functional Medicine, sexuality, and psychedelics for mental health and life direction.

You can find Dr. Kit at the following:

https://kityoon.com/

https://kityoon.substack.com/

https://www.instagram.com/drkityoon/

https://www.facebook.com/yoonacupunctureandcoaching?mibextid=wwXIfr

In this 187th episode, I pop in quickly after a short trip to Northern California for my 51st birthday.

I discuss my feelings of surprise and awe, at what I saw up on the Lost Coast of California. And express my sincere believe that magic is there to help you heal if only you let it.

Please enjoy this short riff on living life in a way that supports our spirits.

In this 186th episode I discuss caffeine and the lovely beverages with which we consume it!

We will discuss how caffeine impacts our brain, blood pressure, energy levels, focus, etc. The good and the bad. How much caffeine is too much? Let's find out. And is there any net benefit from drinking things like coffee and tea aside from caffeine?

Caffeine is by far the most consumed drug worldwide. And most of us take it for granted. So sit back with a nice cup of coffee or tea and enjoy the discussion!

In this 185th episode, I discuss some herbs andnutritional compounds that the medical literature has shown to support brain health, memory, and cognition.  Things mostof us would love to have a little more of!!

We’ll look at five compounds and herbs used for brainsupport: pregnenolone, Alpha-GPC, ginkgo biloba, breviscapine, and bacopa monnieri. How might pregnenolone relate to mood, memory, and neuroplasticity?

And what do you know…  They are all in one handy formula! 

What if I told you I could shed eight pounds, rediscover my defined abs, and significantly improve my blood markers in just five weeks? It sounds like the holy grail of fitness—but for me, it came with a significant price.

In this 184th episode, I’m pulling back the curtain on my personal case study with Retatrutide, an experimental 'GLP-3' peptide currently making waves in the weight loss and biohacking communities.

I’ll break down exactly what this compound is, how it differs from traditional GLP-1 drugs like Ozempic, and why I, for one, found it to be a powerful but double-edged sword.

I will share the raw data I collected—the dramatic changes in my body composition and lab results—balanced against the reality of significant GI distress, muscle fatigue, and an unsettling, yet interesting psychological pull of a 'shortcut' to body perfection.

Whether you’re curious about the science behind the next generation of weight-loss peptides, or you’ve been considering experimenting with them yourself, you need to hear this experience. I’m sharing the good, the bad, and the uncomfortable so you can make an informed decision. Let’s dive in.

In this 183rd episode, we take a closer look at a compound with a surprisingly long and fascinating history: methylene blue. Initially used as a textile dye in the 1800s, methylene blue has since found applications in medicine and surgery, and—more recently—conversations about mitochondrial function, energy production, and chronic illness.

My guest is Dr. Scott Sherr, an internal medicine physician, hyperbaric oxygen therapy specialist, Director of Education at HOMeHOPe, and Chief Medical and Health Education Officer at Troscriptions. Dr. Sherr brings a broad perspective to this topic, connecting the biochemistry of methylene blue with practical questions about chronic fatigue, fibromyalgia, autoimmunity, cancer-related fatigue, and mitochondrial support.

We’ll also discuss why Troscriptions uses a troche delivery system, how methylene blue may fit alongside hyperbaric oxygen therapy or red-light therapy, and—perhaps most importantly—where caution is needed. We’ll explore contraindications such as G6PD deficiency, potential medication and substance interactions, and questions surrounding methylene blue and psychedelic compounds, including classic psychedelics, ketamine, and MDMA.

And because wellness is never just about one molecule or one intervention, we’ll also talk about the nervous system. What does it mean to help someone move out of chronic sympathetic activation and toward a more parasympathetic, restorative state? And why might that shift be essential for healing, recovery, and resilience?

Let’s get into it with Dr. Scott Sherr.

If you would like to try out Troscriptions formulas, you can click this link!

https://hcp.troscriptions.com/join/71f20546-eff8-4ec2-9c6b-2757655e9618

Links & Websites:

Troscriptions.com

drscottsherr.com

homehope.org

onebasehealth.com

Instagram: https://www.instagram.com/troscriptions/

https://www.instagram.com/drscottsherr/

https://www.instagram.com/onebasehealth/

https://www.instagram.com/homehopeorg/

Youtube: https://www.youtube.com/@troscriptions

https://www.youtube.com/@drscottsherr

Linked In: https://www.linkedin.com/in/drsherr/

https://www.linkedin.com/company/troscriptions/

In this 182nd episode, I explore a more subtle connection between anxiety and constipation...

Have you ever felt anxious without knowing why—only to realize that your digestion has been stalled for days?

Constipation isn’t always just about how often you have a bowel movement. It can also involve a breakdown in communication between the gut and the brain. When gut movement slows, bloating and pressure can build. And when the body’s sensory signals are muted, you may not feel the usual urge—or even much pain.

At the same time, the nervous system may still be receiving subtle signals that something is wrong. When those signals aren’t clearly interpreted, they may show up as generalized anxiety, restlessness, or unease.

In this episode, we’ll explore the connection between constipation, the vagus nerve, interoception, and anxiety—and consider how digestion and emotional well-being are deeply connected.

Because sometimes, the question isn’t only, “Why can’t I go?” It’s also: What is my body trying to tell me?

What if overcoming suffering isn’t about escaping pain, but learning how to meet it?

In this 181th episode, I explore ideas inspired by Buddhist teachings as interpreted by the Eastern philosopher Alan Watts, and consider whether our fear of suffering may sometimes become part of the suffering itself.

The Buddha taught that life includes dukkha—a kind of discomfort, dissatisfaction, and impermanence. We naturally seek pleasure and try to avoid pain, but perhaps peace comes not from choosing one over the other, but from learning to be present with both.

In this episode, we’ll explore what happens when we stop resisting discomfort and begin observing it directly. We’ll consider pain, childbirth, grief, illness, and even death—not as experiences to romanticize, but as natural parts of life that may hold the possibility of transformation.

Perhaps wellness isn’t the absence of suffering. Perhaps it’s the ability to remain present, grounded, and connected—even in the midst of it.

In this 180th episode, we explore intestinal permeability and the delicate gut barrier that helps separate the contents of the digestive tract from the rest of the body. We’ll discuss the role of tight-junction and barrier-associated proteins, including occludin, zonulin, and actomyosin, as well as the kinds of immune markers evaluated by tests such as Cyrex Labs Array 2.

We’ll also define autoimmunity: what happens when the immune system loses tolerance to the body’s own tissues. Using examples such as Hashimoto’s thyroiditis, multiple sclerosis, and lupus, we’ll consider whether antibodies against gut-barrier proteins necessarily indicate a direct autoimmune attack—or whether they may also reflect tissue damage, inflammation, and the immune system’s attempt to clean up injured tissue.

The conversation goes further, examining the close relationship between intestinal permeability and autoimmune disease. A compromised gut barrier may contribute to increased immune reactivity, while autoimmune conditions may themselves impair the gut’s ability to maintain a healthy barrier. Because proteins such as occludin and zonulin are also found in other barrier tissues—including the blood-brain barrier and lung barrier—this process may have implications for symptoms such as brain fog, environmental sensitivities, and systemic inflammation.

Finally, we’ll discuss ways to help interrupt this self-reinforcing cycle, including identifying dietary triggers, supporting gut-barrier integrity, improving immune regulation, and addressing the broader foundations of wellness.

Cyrex Labs: https://www.cyrexlabs.com/CyrexTestsArrays/tabid/136/Default.aspx