Analyzing over 11,000 gene-expression samples across mice, rats, macaques, and humans, researchers find a shared molecular signature of aging, with genes like CDKN1A, LGALS3, and GPNMB recurring across species and tissues. They build clocks that predict not just chronological age but mortality risk, catching both accelerated aging and life-extending interventions like caloric restriction. Validated against human blood data, the clocks add interpretability that DNA methylation clocks lack.

This episode was generated by AI from the cited research paper.