Today we provide a comprehensive educational framework for medical students to master the diagnosis of acid-base imbalances. This episode features a simplified five-step methodology that guides students and clinicians through analyzing pH levels, carbon dioxide, and bicarbonate to identify respiratory or metabolic conditions. Advanced diagnostic tools such as anion gap calculations and delta ratios are included to help detect complex or mixed disorders. Practical application is emphasized through clinical case studies and detailed answer keys that demonstrate how to interpret real-world patient data. These instructional documents appear to be part of the UWorld digital learning platform. Consistent with medical training, this episode uses the ROME mnemonic to help learners remember the relationship between different physiological markers.