The sermon centers on the importance of fulfilling the Great Commission, emphasizing that a life dedicated to serving Jesus brings profound joy despite hardships. Drawing from personal experiences, including overcoming a life-threatening accident and supporting family, the speaker underscores the necessity of prayer, active outreach, and financial giving to spread the gospel worldwide. Rooted in Romans 10, the message challenges listeners to embrace a deep compassion for souls, prioritize biblical understanding, and actively participate in sharing the message of Christ, ultimately urging them to support missionaries and prioritize the spread of the gospel to all nations.