In 1783, Philadelphian Elizabeth House Trist left for Pittsburgh, beginning a journey that would take her down the Ohio and Mississippi Rivers hoping -- after seven years of separation during the Revolutionary War -- to reunite with her husband in Natchez.

Trist's travel diary, created at the request of Thomas Jefferson, is the earliest known record of a Mississippi River expedition by woman. A full 20 years before Lewis and Clark recorded their journey through the same waters, Trist filled her journal with natural history observations not only of the landscape, geography, weather, plants, and animals she encountered but with vivid descriptions of the people she met along the way. Trist's eventful journey was full of hardships and adventures -- including waist-high snow, muddy and icy roads, cramped living conditions, treacherous waters, a whirlpool, mosquitos, and a possible encounter with an alligator.

In this episode of In the Course of Human Events, Monticello Guides Lou Hatch, David Thorson, and Holly Haliniewski recount Trist's travels, why Jefferson considered her “amongst my best friends,” and share details of her adventures and the series of tragic deaths that led her to life as one of Monticello's long-term guests.